Résumé
With the global influence of the COVID epidemic, network public opinion control is particularly important especially for the purpose of stabilizing the panic at home and abroad. Effective public opinion collection and caching mechanism has a positive significance for the rapid spread of network public opinion. Therefore, by analyzing the accurate and rapid requirements of public opinion communication, this paper introduces the concept of Information-Centric Networking (ICN) to build a public opinion communication system. At the same time, the corresponding public opinion collection and caching mechanism is designed to optimize the dissemination process of the public opinion. The natural distributed structure of ICN makes the process of public opinion collection and caching distributed. Specifically, a suitable cache server is added between different public opinion collection servers via the distributed search engines. The experimental results show that the proposed distributed public opinion collection and caching mechanism can effectively deal with the spread of public opinion under the environment of the global COVID epidemic, including improving the accuracy of the public opinion transmission in time. © 2022 John Wiley & Sons, Ltd.
Résumé
Background: Surufatinib (a small-molecule inhibitor of VEGFR1-3, FGFR1, and CSF-1R) has exhibited encouraging antitumor activity for the treatment of advanced neuroendocrine tumors (including NEN and NEC) in multiple registration studies. Here, we report the preliminary results of advanced neuroendocrine tumors of an ongoing, multicenter, real-world study of surufatinib + MDT (ChiCTR2100049999). Challenges in tumor clinical trials management in the face of the COVID-19 resurgence period in Shanghai. Methods: In this multicenter, single-arm real-world study, adults (18-80) with advanced neuroendocrine tumors (including NEN and NEC) were eligible and received surufatinib (300mg orally, QD) with MDT（multidisciplinary collaborative diagnosis and treatment). The primary endpoint was progression-free survival (PFS) per RECIST 1.1. We minimized the interruptions caused by the pandemic using telemedicine platforms for all patients. This included online consultations, follow-up drug distributions, and health management services. Results: Twenty-three pts were enrolled, with 20 NEN and 3 NEC. At the data cutoff date (April 10, 2022), 15 pts had at least one post-baseline tumor assessment;of them, the confirmed ORR (95%CI) was 20% (4.3-48.1), and DCR (95%CI) was 93.33% (68.1-99.8). Median PFS (mPFS) (95%CI): 10.640 mo (3.796-17.484);median OS: not reached and median duration of follow up was 6.870 mo (6.797-6.943). A pNET patient (NO. 010007) was interrupted by asymptomatic COVID-19 infection 9 mo after enrollment. There are no interruptions caused by COVID-19 for other patients. An NEC patient treated with single agent had a 5.85 mo PFS, evaluated as NE, in whom target lesion resected after baseline. In overall pts (n=23), most commonly (≥3 pts) with hemorrhage, anemia, hypertension, proteinuria, and abdominal pain. Three pts had TRAEs that led to treatment discontinuation. Conclusions: Surufatinib + MDT exhibited promising efficacy and manageable toxicity in pts with advanced neuroendocrine tumors. Now and in the future, it is necessary to design regulatory changes in telehealth adoption for clinical trial design in the pandemic era. Clinical trial identification: ChiCTR2100049999. Legal entity responsible for the study: The authors. Funding: Hutchison MediPharma Limited. Disclosure: All authors have declared no conflicts of interest.
Résumé
With the global influence of the COVID epidemic, network public opinion control is particularly important especially for the purpose of stabilizing the panic at home and abroad. Effective public opinion collection and caching mechanism has a positive significance for the rapid spread of network public opinion. Therefore, by analyzing the accurate and rapid requirements of public opinion communication, this paper introduces the concept of Information-Centric Networking (ICN) to build a public opinion communication system. At the same time, the corresponding public opinion collection and caching mechanism is designed to optimize the dissemination process of the public opinion. The natural distributed structure of ICN makes the process of public opinion collection and caching distributed. Specifically, a suitable cache server is added between different public opinion collection servers via the distributed search engines. The experimental results show that the proposed distributed public opinion collection and caching mechanism can effectively deal with the spread of public opinion under the environment of the global COVID epidemic, including improving the accuracy of the public opinion transmission in time.
Résumé
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been confirmed as the etiological pathogen of the coronavirus disease 2019 (COVID-19). SARS-CoV-2 is the seventh member of coronavirus family that can infect humans after the emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV). SARS-CoV-2 is a single-stranded, positive-sense RNA virus. Due to its strong infectiousness and the lack of immunity in humans, the epidemic of the COVID-19 is still spreading. On January 30, 2020 (local time), the World Health Organization (WHO) defined the epidemics of SARS-CoV-2-infected pneumonia as a Public Health Emergency of International Concern (PHEIC). This paper reviews the etiology and pathogenicity of SARS-CoV-2, and the detection and diagnosis, prevention and control, as well as the treatment of COVID-19.
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Objective: To understand the coronavirus disease 2019(COVID-19)prevention and control work and the problems and difficulties faced by non-government primary medical institutions in China during the epidemic period. Methods: A survey on the coronavirus disease 2019(COVID-19)prevention and control work of non-government primary medical institutions was conducted on April 14 to 21, 2020 with the self-designed questionnaire. The questionnaire contained three parts: the first part was basic information of medical staff in non-government primary medical institutions, including position and institutional information;the second part was the status quo of non-government primary medical institutions participating in the prevention and control of COVID-19, including the specific work and difficulties faced by the responders during the epidemic period;and the third part was the prevention and control effect of COVID-19 in the responders' institutions, including whether there were confirmed cases and infected medical staff. An online invitation was issued among the members of General Practice Branch of Chinese Non-government Medical Institution Association. The invited participants included the heads, general practitioners and other medical personnel of the non-government primary medical institutions the invited participants voluntarily scanned the online two-dimensional code to fill in. Results: A total of 761 individuals in primary health institutions from 20 provinces, municipalities and autonomous regions in China participated in the survey. There were 290 (38.1%) men and 471 (61.9%) women with age of 40(32, 48) years;83.0% (632/761) had worked for more than 5 years;33.8% (257/761) owned primary professional titles and 33.0% (251/761) owned intermediate titles. Among all participants 28.5% (217/761) were general practitioners, 26.9% (205/761) were institutions/department managers, 14.6% (111/761) were specialists and 40.3% (307/761) were other related personnel. A total of 549 institutions continued to operate during the epidemic period and 96.5% (530/549) participated in the work related to the prevention and control of the epidemic, including prescreening and triage, health consultation, follow-up of suspected patients, donation, quarantine of suspected cases, follow-up of close contacts/discharged patients, diagnosis and treatment of patients with new coronavirus pneumonia. 44.7% (340/761) of respondents participated in the epidemic prevention as front-line staff and directly contacted patients/suspected patients, and 63.1% (480/761) participated in the epidemic prevention work of primary medical institutions, including clinical outpatient service, prescreening triage and screening. The working sites were not limited to the institutions, but also other sites including high-speed railway station. The 97.8% (744/761) responders expressed their willingness to participate in epidemic prevention work under the unified leadership and command of the state. The 63.9% (486/761) of the responders were worried about the lack of protective equipments and measures, and 90.4% (688/761) respondents showed that they needed medical supplies (protective equipment: masks, goggles, protective gowns, etc.). Conclusion: The participation of non-government primary medical institutions and their staff in COVID-19 infection prevention and control is a key component of the epidemic prevention process. © 2021 Chinese Medical Association
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The outbreak of coronavirus disease 2019 (COVID-19) in Dec. 2019 sounded another alarm for humanbeing, with the first being the outbreak of severe acute respiratory syndrome (SARS) in 2003. Researchers found that the natural host of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen of COVID-19, may be the Rhinolophus sinicus. There have been four outbreaks of coronaviruses (severe acute respiratory syndrome coronavirus [SARS-CoV], Middle East respiratory syndrome coronavirus [MERS-CoV], swine acute diarrhea syndrome coronavirus [SADS-CoV] and SARS-CoV-2) worldwide since the beginning of 21st century, and they have caused huge threats and losses to human health, public health, economic development, and social stability. A large amount of evidence suggests that the natural host of all these four coronaviruses may be bats. This article reviews the species and global geographic distribution of bat-related coronaviruses, and the above-metioned four coronaviruses causing severe outbreaks.
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SARS-CoV-2 has characteristics of wide contagion and quick propagation velocity. To analyse the visual information of it, we build a SARS-CoV-2 Microscopic Image Dataset (SC2-MID) with 48 electron microscopic images and also prepare their ground truth images. Furthermore, we extract multiple classical features and novel deep learning features to describe the visual information of SARS-CoV-2. Finally, it is proved that the visual features of the SARS-CoV-2 images which are observed under the electron microscopic can be extracted and analysed. © 2020, Springer Nature Switzerland AG.
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Objective To explore the diagnosis and treatment process and experience of emergency interventional ultrasound in our hospital under the coronavirus disease 2019 (COVID-19) epidemic situation, so as to provide reference for the safe and effective implementation of interventional ultrasound during the epidemic. Methods This study summarized and reviewd the experience of interventional ultrasound for the diagnosis and treatment of three emergency patients in the department of ultrasound of our hospital during the COVID-19 epidemic, focusing on the screening of severe COVID-19 patients, the selection of indications for interventional puncture, the perioperative protection and postoperative management. Results According to epidemiological screening, patient 1 had close contact with the confirmed COVID-19 patient. Chest CT showed diffused interstitial exudation in the lower lobes of both lungs, and the patient was seen as a suspected case after consultation with the hospital expert group, who had retropharyngeal space infection on admission and needed to remove the infection focus quickly. COVID-19 was excluded in patient 2, who was diagnosed as acute episode of calculous incarcerated cholecystitis on admission, requiring rapid drainage of bile to relieve gallbladder obstruction. Patient 3 was excluded from COVID-19 and diagnosed as acute pericardial tamponade on admission, requiring rapid drainage of pericardial effusion. All 3 patients underwent strict COVID-19 screening procedures to identify the indications of interventional puncture. During the operation, tertiary protective measures were adopted for patient 1, and primary protective measures were adopted for the other two patients. Three severe patients were successfully treated by interventional ultrasound, with short average time, less bleeding and improved clinical symptoms. Conclusion Interventional ultrasound is minimally invasive, convenient and efficient, making it suitable for the emergency treatment during the COVID-19 epidemic. It can be used as an alternative to some emergency surgery, or provide a safe window period for confirmed or suspected severe COVID-19 patients. Our experience may provide a reference for the safe and effective practice of interventional ultrasound during the COVID-19 epidemic..